PED Profiles: Anadrol (Oxymetholone)

Performance Enhancing Drug Profiles

Anadrol (Oxymetholone)

By Dr.X

Dr.X is back with a new column here at Power Nutritionist. The purpose is to provide readers with an accurate understanding of different performance-enhancing drugs not only from a medical angle but also what goes on in the back alley gyms all across America. It will provide a refreshing balance of science and street knowledge and application that will be unparalleled. For those of you who want to truly know the ins and out of what really happens behind the scenes with both professional and national level amateurs from different sports, this is the column for you. Like all my columns, this will be totally uncensored with a no holds barred style that I am known for. If profanity or truth offends you…Leave Now!


Oxymetholone or what is known as Anadrol is one of the strongest steroids of all time for packing on muscle mass. This is why it is favored by bodybuilders in the offseason as well as strength athletes like powerlifters and strongman competitors. It was released into the market in the late 1950s by the very popular company Syntex, and the strength world has never looked back. It is a powerful anabolic steroid derived from Dihydrotestosterone. For the novice, gaining 20-30 pounds in as little as 4 weeks is not uncommon. While a decent portion will be from water retention, it will stimulate rapid muscle growth as well. Major increases in strength and power are also noted. Gaining 50-100 pounds on your bench press during an Anadrol cycle is the norm, not the exception. For its medical benefits, it is mainly used to help increase hemoglobin levels for those that suffer from anemia. Once AIDS hit the scene in the 1980s, it has also been used to help treat this virus and other muscle-wasting conditions.

Anadrol Was a Huge Benefit for AIDS Patients in the ’80s

Structural Characteristics

Oxymetholone is a modified form of Dihydrotestosterone. It differs by 1) the addition of a methyl group at carbon 17-alpha, which helps protect the hormone during oral administration, and 2) the introduction of a 2-hydroxymethylene group, which inhibits its metabolism by the 3-hsd enzyme and greatly enhances the anabolic and relative biological activity of Methyldihydrotestosterone.

Layman’s Understanding

So to break this down into layman’s terms, Anadrol is a modified form of DHT but has an added methyl group that allows it to be more active in muscle tissue than its parent compound. It has an anabolic rating of over three times that of Testosterone with a score of 320. For those that are not sure what this means, you should know that Testosterone rates a score of 100. So as you can see its anabolic factor is much higher. What many may find hard to believe but true is that Anadrol’s androgenic strength rating is only 45 on this chart while again Testosterone comes in at 100.

For the aggression that can be felt when on Anadrol, most would think that its androgenic factor rating would be much higher than Testosterone. This is because when on even 1000mg of Testosterone per week, most men actually feel very happy and in a good mood. They feel confident, successful, and optimistic in many of life’s areas. But for those on as little as two Anadrol tabs per day, it’s a completely different story. You get agitated much faster than normal, and if someone rubs your balls the wrong way, you can best rest assured you’ll be delighted to rip them a new asshole in record time.

Getting Agitated on Anadrol is a Reality!

The structure and composition of Anadrol have noted another benefit as well. It has been shown in studies to help lower Sex Binding Hormone Globulin (SHBG). For those of you not familiar, this globulin will basically bind with your free-floating Testosterone and make it useless. So by reducing SHBG you will have higher circulating levels of Testosterone which is exactly what you want.

Side Effects

Ok now we get to the meat and potatoes here boys and girls. Now I am going to start with the estrogenic effects that need to be noted. High levels of estrogen can occur when taking Anadrol. For those of you who have seen your once skinny buddy all of a sudden sport a moon face in three weeks now understand why this occurs. You need to watch out for Gyno (Bitch Tits), water retention, increased blood pressure, acne, and aggression issues.

Gyno is Something You Want to Avoid at All Costs!

What many of you may be asking right now is that since it is a DHT derivative, why are you getting estrogen related side effects? Well, Anadrol does not fit the profile for DHT compounds that is for sure. For those of you who know a little bit about DHT compounds like Winstrol, Masteron Propionate, etc, they usually help you get hard as nails and dry. They also don’t aromatize into Estrogen. This is why they are used by bodybuilders during their contest prep to bring a dry and striated physique to the stage.

Since Anadrol does not interact with the Aromatase enzyme, drugs like Arimidex, Aromasin, and Letrozole will not help combat your Estrogen issues. This is where Nolvadex (tamoxifen citrate) comes in and will help in this regard because it is a Selective Estrogen Receptor Modulator (SERM) and not an Aromatase Inhibitor (AI).

Nolvadex Is a Must When on Anadrol!

Since Anadrol is a DHT compound some individuals may suffer from prostate hypertrophy and loss of hair. Since the prostate and the scalp contain the highest number of DHT receptors, the binding affinity is a concern when taking Anadrol. If you are prone to hair loss or prostate issues which can be most men after the age of 40, listen up. If you are going to use Anadrol make sure to take preventative measures to stay healthy.

Let’s not forget that Anadrol is an oral steroid and C-17 Alpha Alkylated one at that. What that means is this bad boy has to be passed through your liver twice before it can get to work. This means watching your liver enzyme count is a must because it can get out of control if you decide to run it at a high dose. The two most important liver enzymes to watch out for when on Anadrol is Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST). This is why those who do use Anadrol should have a good liver protection stack on hand, and use it for the duration of your cycle.

Let’s not forget the ladies here either. This is definitely not something ladies should be taking at all. Its androgenic effects will dramatically cause virilization badly. Your face will take on a whole other dimension in terms of masculinity. Unless that is something you want to happen do not touch this drug. Do some women take Anadrol? The answer is yes. Pro women bodybuilders and powerlifter do partake but you have to weigh the consequences. Unless competing in the Ms. Olympia is your lifetime goal, using another lighter compound would be a better choice.


Anapolon from Turkey is Amazing Anadrol!

Let’s get back to the blood pressure issue for a minute. Now Anadrol is notorious for jacking your blood pressure up especially when you are trying to pack on mass or eating a higher caloric intake. The fact is when guys are on cycle and trying to get their weight up, their diet is not as clean as it could be. With that being said, their sodium intake is also much more than usual. The combination of continual weight gain, increased sodium consumption, and eating Anadrol like its candy, can wreak havoc on your blood pressure values. How many of you have seen powerlifters get nose bleeds while bench pressing or squatting? Yea I am sure you all have, as it’s quite common. Well, that is high blood pressure right there my friend. What that really is, is the Anadrol buffet he had for breakfast kicking in hard. The next time you see a powerlifter blow blood on the first three rows from his nose during a squat attempt, you should be thinking “I wonder how many tabs of Anadrol this guy is on?”

Nose Bleeds on Anadrol are Common in High Doses!

Cycling Information

Now like I mentioned earlier Anadrol is a great addition to an offseason bodybuilding stack or for strength athletes looking to gain weight and power for an upcoming competition. It is usually stacked with other mass-producing long estered compounds like Testosterone Enanthate, Sustanon, Deca Durabolin, and Equipoise. As you know except for the EQ, all of those compounds will also easily help you pack on the bloat like a water buffalo so keeping that svelte look on a stack with them isn’t happening unless you are an ectomorph or someone that keeps their diet very clean all year round. Most will use two injectables and then run Anadrol for their oral for the first four weeks of their cycle to help kickstart the gains into play. While some may use it up to six weeks at a time, that would be pushing the envelope on toxicity so anything longer would not be advisable.


Anadrol definitely has a cult following among hardcore bodybuilders and strength athletes. This is due to the fact that nothing puts on mass and bulk faster. It is a favorite with Powerlifters and Strongman competitors especially in the last weeks before a competition. The usual dose for the oral version is 50-100mg per day in divided applications. This dose is the most common among beginners and gym rats. Some will cut the 50mg tabs in half to break up the dose to help keep a more stable influx every 4-6 hours. The active half-life is about 16 hours so even spreading out your daily dose over two servings is more than enough. Many like to take it about an hour before training. This will cause a large spike in aggression and strength gains during your workout. Not to be forgotten is the crazy pump it will give you as well. You will actually feel it kicking in as you train. For those of you competing in drug-tested events, you should know that it can be detected for up to eight weeks after discontinuing its use.

Underground Street Applications

So here is where it gets juicy boys and girls. So if you don’t like a dose of reality it may be time for you to go protest for global warming or chain yourself to a tree in the forest trying to save the planet. Anadrol is truly one very badass drug that is without a doubt. But hell you already know that after all my ramblings above. Now studies have shown that taking more than 100mg per day will not produce any more strength or muscle mass gains than keeping at 100mg per day. Now like I have said before, I do respect science obviously, but what goes down in a study is not always what happens in real life. So if the above information is true why do so many strength athletes take much more than 100mg per day? Well, the answer is that when they took 3, 4, or 5 Anadrol tabs per day they obviously notice they kept getting stronger and stronger.

In fact, I personally know of one world record holder in the bench press who was one of the first to hit over 900 pounds some time back who loved the A-Bombs. He took an astonishing ten Anadrol 50 tabs per day. Yes, you heard that correctly folks. I am sure you can figure out who that may be as his head was the size of a pumpkin and his face had “I suffer from high blood pressure” all over it. Yes, you may doubt what I am saying but I have no reason to blow hot steam up your ass with lies and deceit. It really gets me nowhere to make up fictional stories and that is not what I am about. So believe me if you will, or call me a liar it’s your choice. I know for fact what I am saying is the truth even though many of you will not accept what really happens behind the scenes.

Anadrol is a Strength Athletes Dream Come True!

Another world-class powerlifter in the 181-pound class that smashed records like they were nothing also had a deep appreciation for this drug also. He would take five Anadrol tabs per day for the last 4 weeks before a competition. His naturally ectomorphic body type responded very nice to this drug and his strength in the last weeks before competing would dramatically change for the better. But please don’t think that this is only limited to powerlifters. I also do know of one pro bodybuilder who also took that magic ten tabs of Anadrol per day as well. He was a top Canadian pro that was famous in the late 1980s and early 1990s. The funny thing about him is that he never denied the story ever. Today all the pros say they take 500mg of Testosterone and 300mg of Tren to get ready for their Olympia performance. They lie right through their teeth. This cat told the truth and didn’t care what anyone thought and neither should you.

But strength gains are not only why so many love this drug. Due to the increased water retention, your joints will feel young and fresh again. When you have been clanging and banging for twenty-plus years your joints have been through more of a beating than some porn star’s vagina. With that visual still engraved in the frontal lobe of your brain, I will say that Anadrol can make those achey painful joints feel like you are a youngster again.

Your Joints Will Feel Awesome on Anadrol!

The other benefit and the main purpose behind its creation is the increased red blood cell count. For those of you who have taken this wonder drug before you can attest to the increased pumps where you feel indestructible. It is also favored by endurance athletes to help increase their stamina and not having to resort to blood doping or EPO. Yes once again I may shock you but I do know of one world-level cyclist that uses high amounts of Anadrol 50 in the weeks before the competition. Cyclists are some of the biggest abusers of drugs, but since they don’t look jacked to the max they are less criticized.

Bodybuilders like Anadrol in the offseason and that is a common practice but did you know that many also like it pre-contest? You may think that I have lost my marbles on this one but no I haven’t at least not yet. You see when a bodybuilder is severely depleted on a calorie defect, hitting an hour and a half daily of cardio, and training in the gym twice daily, their body is like a sponge. Many elite bodybuilders will take Anadrol in the last 7 days before the competition. This will help fill out their physique very nicely. It will prevent that stringy look for those that over dieted and miscalculate the diuretics effects in the last hours before stepping on stage.

Anadrol Can Make your Muscles Full and Dialed In!

The other thing that has to be taken into account is your appetite while on Anadrol. Now Syntex wanted it to increase appetites and it does to a point. You see when you take one tab per day it will make you hungry like you want to eat everything in sight. But bump that up to three tabs per day and you will not even want to look at food. For bodybuilders, this is even worse when they try and eat their third meal of tilapia and broccoli because healthy food will be harder to get down than a large pizza and side order of spicy wings. Now I have a trick that can help with this issue and I will be discussing it in a future column. This is something you want to avoid because eating is a must when trying to pack on mass. If Anadrol drops your appetite then you will not truly benefit from all it has to offer. Staying hungry is critical.

The other side effect that I forgot to mention is the increased sex drive. Ok, many of you reading this may think that it is a good thing not a bad thing. Well, a slight increase in your libido can be great, but if it gets so out of control that you feel like fucking everything on two legs, then it could start to be a problem. You see many of you may be in a relationship either married or have a girlfriend. Now staying monogamous while on Anadrol is much easier said than done. If you are only taking one tab per day you will definitely notice that frisky feeling kicking in much more than usual. But if you are a seasoned competitor and are taking five Anadrol tabs per day you will be salivating at just about any poonany that walks your way. In fact, when you are on Anadrol women that you would ever even consider having sex with will look like prime rib when you are on a cycle. Yea it is that bad believe me. It gets so bad that some guys using large doses have a constant sperm drip in their pants. Basically, it’s pre-cum leaking all day long due to the crazy sex drive that you have going on. So be warned, if you decide to use Anadrol especially in higher doses, you will turn into a sex fiend!

Was Louis C.K. on Anadrol?


So I set out to provide you with one of the most real deal breakdown of the famous steroid Anadrol. As you can see it is one of the strongest orals in existence and this is why it is favored by elite athletes in numerous sports. Not only did I cover some of the scientific and medical angles of Anadrol but also wanted to give you some personal insight into this compound as well. With my time in the trenches being surrounded by world-class athletes I have seen some crazy things. If Anadrol is something you are considering taking in your performance protocol, then make sure to protect your health as the first priority. Sooner or later it will be time to pay the piper. When the piper comes a calling, you want to make sure you have all your ducks lined up in a row and come correct!

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